Pipeline

The Future of Drug Discovery


At Cullgen, we believe that the key to advancing medicine lies in redefining the way we approach drug discovery. Our pipeline harnesses the power of state-of-the-art technologies, immense expertise, and an unwavering dedication to developing transformative therapeutics. It is designed to expedite the journey from target identification to clinical candidates, streamlining the drug discovery process and bringing novel treatments to patients faster than ever before. Committed to collaboration and open innovation, our pipeline also offers strategic partnerships with leading biopharmaceutical companies. These alliances foster synergistic advancements in drug discovery, fostering valuable collaborations that enable us to achieve remarkable breakthroughs together.


At Cullgen, our discovery pipeline is poised to revolutionize the field of drug development. By embracing innovation, leveraging cutting-edge technologies, and fostering collaborative partnerships, we are truly transforming the future of medicine, one breakthrough at a time.

Cullgen Novel E3 Ligand Discovery Pipeline

Broad expression & functional essential

E3A

Broad expression & functional essential

E3B

Tissue Restrictive Expression

E3E

E3G

Tumor Enriched Expression

Functional Validation

E3 Selection

E3 Binders Discovery

Lead Optimization

Target

Cullgen Therapeutic Programs: Focused on Cancer

Indication

Target Selection

Lead Optimization

Breast cancer and multiple solid tumors

Hit Discovery

Prostate, lung, and bladder cancers

Breast and ovarian cancers

Cell Cycle (a)

Immuno-oncology of multiple cancer types

Cell Cycle (b)

DNA repair

Metabolism

PCC Selection

IND Enabling

Partnered with Astellas

Clinical trial initiated

Non-enzyme target

Utilizing Cullgen E3 ligands

Phase I

Colon, ovarian, and GI cancers

Solid Tumors

TRK

TRK

Translation

Transcrip-tion

Epigenetic

Acute and chronic pain

Leukemia and MYC+ Cancers

Lymphoma

Descriptions of the projects that are furthest advanced:

Cullgen Novel E3 Ligand Discovery Pipeline

Explanation about this pipeline

Cullgen Therapeutic Programs: Focused on Cancer

Explanation about this pipeline